Composite

Part:BBa_K5057007:Design

Designed by: Jan Zielinski   Group: iGEM24_Freiburg   (2024-09-20)


Sushi S1 antimicrobial peptide with extracellular signal peptide HSTII


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]


Design Notes

Source

Sushi S1 antimicrobial peptide is derived from Factor C from horseshoe crab [1]. The HSTII sequence is derived from Heat-Stable Entertoxin 2 from E.coli [2].

References

[1] Yau YH, Ho B, Tan NS, Ng ML, Ding JL. High therapeutic index of factor C Sushi peptides: potent antimicrobials against Pseudomonas aeruginosa. Antimicrob Agents Chemother [Internet]. 2001;45(10):2820–5. Available from: http://dx.doi.org/10.1128/AAC.45.10.2820-2825.2001 ‌

[2] Sjöström M, Wold S, Wieslander A, Rilfors L. Signal peptide amino acid sequences in Escherichia coli contain information related to final protein localization. A multivariate data analysis. The EMBO Journal. 1987 Mar;6(3):823–31.